Diagnostic Tests

CLINICAL ASSOCIATIONS

Mitogen’s Anti-PLA2R is an autoimmune diagnostic test that detects autoantibodies against phospholipase A2 receptors (PLA2R). The results are useful in the diagnosis of idiopathic membranous nephropathy. When this test is negative, testing for antibodies to thrombospondin should be considered in the diagnosis of primary membranous nephropathy (MGN, pMGN), formerly known as idiopathic membranous nephropathy (IMN).

The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family that includes the mannose receptor. Being both a transmembrane glycoprotein receptor and a soluble receptor, PLA2R regulates a variety of biological responses through binding phospholipase A2. PLA2R’s function includes the induction of cell proliferation, cell migration, and lipid mediator production.

Reference: A. Behnert, M. Schiffer, J. Muller-Deile, L. H. Beck, Jr., M. Mahler, M. J. Fritzler. Antiphospholipase A2 Receptor Autoantibodies: A Comparison of Three Different Immunoassays for the Diagnosis of Idiopathic Membranous Nephropathy. J.Immunol.Res. 2014:143274, 2014.