CLINICAL ASSOCIATIONS

MitogenDx’s COVID-19 (SARS-CoV-2) Antibody Serology Test detects antibodies (IgG) against COVID-19 Spike Protein (S1 subunit), COVID-19 Nucleocapsid Protein, and COVID-19 Receptor Binding Domain.  A positive test indicates exposure to the SARS-CoV2 virus and an immune response to SARS-CoV2 vaccines.  Results provided show semi-quantitative levels of antibodies against these three critical COVID-19 / SARS-CoV-2 antigens (targets) and generates a final report on COVID-19 immunity.

What is an antibody serology test?  One of the most dynamic features of your body’s immune system is its ability to recognize something foreign (such as a virus or unwanted bacteria) and to develop a corresponding targeted attack.  Antibodies (also known as immunoglobulins) are robust proteins that are uniquely designed and produced by your body’s immune system that seek out foreign targets.  When an antibody finds its target it acts as a homing beacon for immune cells to initiate the destruction and removal of the foreign substance.  In the case of a viral infection or vaccination, your body will raise an immune response against the virus (or vaccine) which in-turn inhibits the virus’s ability to replicate and cause harm to your body.  There are a number of different antibody/immunoglobulin classes that have different features and functions.  The most common antibody class that is involved with long-term immunity is IgG.  An antibody serology test is a test completed on a blood sample to detect the presence of specific antibodies.  In the case of Eve Technologies’ COVID-19 Antibody Serology Test, IgG antibodies that are required for COVID-19 immunity (antibodies against COVID-19 Spike Protein (S1 subunit), COVID-19 Nucleocapsid Protein, and COVID-19 Receptor Binding Domain) are independently detected giving a semi-quantifiable result.

Why is antibody testing important?   Knowing if you have antibodies against COVID-19 not only indicates if you’ve had an infection in the past, it also gives indications towards an active infection, the success of immunization, and the total scope of your immunity against COVID-19.  The immunity gained through antibody production is not guaranteed to be long-term.  Few vaccines and the resulting antibodies and the cells programmed to produce specific antibodies (B-cells) remain effective for life.  Some have an efficacy for a number of years, and others are only viable for a number of months or even weeks.  Although antibodies against COVID-19 likely provide some immunity (dependent on antibody levels and the presence of neutralizing antibodies that inactivate the virus) there is currently not enough evidence to know how long the antibodies last or to what extent past infection with the virus helps protect you from getting another infection.  Therefore it is important for individuals, employers, and society in general to know what your COVID antibody status is today and in the future.

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