Diagnostic Tests

LES ASSOCIATIONS CLINIQUES

Complement Panel 4: The diagnosis of Hereditary and Acquired Angioedema can be supported by determining the levels and function of C1 inhibitor (C1 INH), a critical regulator of the classical complement pathway. This panel is essential for diagnosing and monitoring hereditary angioedema (HAE) and acquired angioedema (AAE). In HAE, deficiencies or dysfunctions of C1 INH lead to uncontrolled activation of the complement system, resulting in episodes of swelling in various parts of the body, including the extremities, gastrointestinal tract, and upper airways. Acquired angioedema, often seen in association with lymphoproliferative disorders, is typically caused by autoantibodies that inactivate C1 INH. This panel is critical for differentiating complement-mediated angioedema from other causes of swelling and guiding treatment decisions, including the use of C1 INH replacement therapies or other targeted treatments to manage and prevent angioedema attacks.