Diagnostic Tests

Anti‐Beta-2 Glycoprotein 1 – Domain 1 Test (D1 β2GP1)

ANTIGENS / BIOMARKERS

Anti-β2Glycoprotein1-Domain 1 (IgG )

TURNAROUND-TIME (TAT)

5 Days

SKU / TEST CODE

Domain

PROCEDURE / TECHNIQUE

Chemiluminescent Immunoassay (CIA)

REFERENCE RANGE

Semi-Quantitative • Negative <20 CU • Positive ≥20 CU

SENSITIVIY / SPECIFICITY

TBD

CLINICAL ASSOCIATIONS

Mitogen’s Anti‐Beta-2-Glycoprotein 1 (β2GP1) – Domain 1 assay is an autoimmune diagnostic test that is useful in the diagnosis of anti-phospholipid syndrome. Antibodies to Domain 1 are reported to be more specific than antibodies to the entire β2Glycoprotein1 protein, which is used in some assays.

β2GP1 has a number of essential functions including the regulation of haemostasis (regulating blood vessel injury and bleeding), homeostasis (general body regulation), and immunity / complement. Consequently, autoantibodies against β2GP1 often leads to arterial or venous blood clots which is a key feature of anti-phospholipid syndrome. There are also associations with migraine headaches and issues with eye sight.

References:
M. Mahler, et al. Autoimmun.Rev. 12:313-317, 2012.
McDonnell T, et al. The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS. Blood Reviews Volume 39, January 2020, 100610.

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