Diagnostic Tests

CLINICAL ASSOCIATIONS

Antibodies directed to the nuclear envelope/membrane components are typically first identified in HEp-2 IFA reports (AC-11, 12). Mitogen’s Nuclear Envelope / Membrane Profile is an autoimmune diagnostic test that provides analysis of the more common autoantibody nuclear envelope/membrane targets. These autoantibodies are seen in primary biliary cholangitis (PBC), systemic lupus, myositis overlap syndromes, systemic sclerosis and other autoimmune conditions.

Autoantibodies to gp210 (AC-12) are relatively specific for PBC and have been reported to portend a poor prognosis. Further diagnostic measures using antigen-specific analysis can help identify a likely clinical correlation such as the AC-11 pattern being associated with antibodies to lamin proteins. This autoantibody presence has been reported in autoimmune-cytopenias, autoimmune liver diseases, linear scleroderma, and other autoimmune conditions.

Reference: S. Mehra, J. Walker, K. Patterson, and M. J. Fritzler. Autoantibodies in systemic sclerosis. Autoimmun.Rev. 12:350-354, 2013.