Diagnostic Tests

CLINICAL ASSOCIATIONS

Mitogen’s Idiopathic Ataxia /Anti‐MPP‐1 assay is an autoimmune diagnostic test that detects autoantibodies to MPP-1. Kinesin-like protein KIF20B, originally named M-phase phosphoprotein 1 (MPP1), is a plus-end-directed kinesin-related protein that exhibits in vitro microtubule-binding and -bundling properties as well as microtubule-stimulated ATPase activity. It has been characterized as a slow molecular motor that moves toward the plus-end of microtubules. Human autoantibodies directed against MPP1 / KIF20B have been described in up to 25% of patients with idiopathic ataxia and less commonly in other neuropathies and autoinflammatory conditions. Unlike paraneoplastic autoantibodies, patients with anti-MPP1 are not known to have a high risk of an underlying malignancy.