Diagnostic Tests

CLINICAL ASSOCIATIONS

Use our Serum Amyloid A (SAA) / ADAMTS13 2-Plex Panel for a targeted assessment of acute phase inflammation and chronic inflammatory diseases.

Serum amyloid A (SAA) is a key biomarker found in serum and plasma that increases during acute inflammatory responses. It plays a role in regulating immune cells and maintaining the balance between pro-inflammatory and anti-inflammatory factors, making it a reliable indicator for autoimmune and rheumatic diseases, such as rheumatoid arthritis, familial Mediterranean fever, sarcoidosis, and vasculitis.

ADAMTS13 is crucial for resolving clots by cleaving von Willebrand factor (VWF) to prevent excessive platelet aggregation. While it is essential in conditions like thrombotic thrombocytopenic purpura (TTP) and von Willebrand disease (VWD), it may also be involved in other vascular inflammation disorders.

Reduced levels of ADAMTS13 have been observed in long COVID patients, indicating hemostatic dysregulation, while SAA is linked to hyperinflammation in COVID-19.

Several biomarkers in this panel are specifically associated with coagulation, which makes serum an unsuitable sample type for this assay. The Serum Amyloid A (SAA) / ADAMTS13 2-Plex Panel is recommended for plasma only, EDTA preferred, and CSF (SAA only) samples.