Scleroderma / Systemic Sclerosis Panel
ANTIGENS / BIOMARKERS
Anti-CENP A + B, Topo-I/Scl-70, RP11, RP155, Anti fibrillarin/U3RNP, Th/To/hPOP1, Ku, PDGFR, Ro52/TRIM21, PM/Scl-75, PM/Scl-100, NOR90/Hubf
SKU / TEST CODE
SCLERO
PROCEDURE / TECHNIQUE
Line Immunoassay (LIA)
REFERENCE RANGE
Qualitative (SI :Signal Intensity) • Negative <10 SI • Weak Positive 11-29 SI • Medium Positive 30-89 SI • High positive >90 SI
SENSITIVITY / SPECIFICITY
TBD
CLINICAL ASSOCIATIONS
Mitogen’s Scleroderma / Systemic Sclerosis Profile is a comprehensive autoimmune diagnostic test for scleroderma-specific autoantibodies directed against CENP, Scl-70/topo I, RNA polymerase, U3-RNP (fibrillarin), Th/To and other scleroderma-related autoantibodies. Each autoantibody (and combinations of autoantibodies) has been associated with clinical subsets of scleroderma.
Reference: M. Y. Choi and M. J. Fritzler. Progress in understanding the diagnostic and pathogenic role of autoantibodies associated with systemic sclerosis. Curr.Opin.Rheumatol. 28:589-594, 2016.
RELEVANT DISEASES
- ANCA-related vasculopathies / glomerulonephritis
- Arthritis
- Arthritis (Juvenile arthritis / Juvenile idiopathic arthritis)
- Arthritis (Rheumatoid Arthritis)
- Asthma
- Autoimmune liver diseases
- Autoimmune mucocutaneous blistering diseases
- Dysphagia
- Interstitial lung disease (ILD)
- Juvenile dermatomyositis (JDM)
- Lupus, Systemic lupus erythematous (SLE)
- Mixed connective tissue disease
- Primary Membranous nephropathy (pMN): aka primary membranous glomerulonephritis (pMGN) and idiopathic membranous nephropathy (IMN)
- Primary biliary cholangitis
- Rheumatoid Arthritis
- Scleroderma / systemic sclerosis
- Sjögren syndrome
- Systemic lupus erythematous (SLE)
PRICES
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