Diagnostic Tests

Scleroderma / Systemic Sclerosis Test Panel

ANTIGENS / BIOMARKERS

Anti‐CENP A + B, Topo‐I/Scl‐70, RNA polymerase III, fibrillarin/U3RNP, Th/To/hPOP1, Ku, PDGFR, Ro52/TRIM21, PM/Scl‐75, PM/Scl‐100, NOR90/Hubf

TURNAROUND-TIME (TAT)

5 Days

SKU / TEST CODE

SSc

PROCEDURE / TECHNIQUE

Line Immunoassay (LIA)

REFERENCE RANGE

Qualitative (SI :Signal Intensity) • Negative <10 SI • Weak Positive 11-29 SI • Medium Positive 30-89 SI • High positive >90 SI

SENSITIVIY / SPECIFICITY

TBD

CLINICAL ASSOCIATIONS

Mitogen’s Scleroderma / Systemic Sclerosis Profile is a comprehensive autoimmune diagnostic test for scleroderma-specific autoantibodies directed against CENP, Scl-70/topo I, RNA polymerase, U3-RNP (fibrillarin), Th/To and other scleroderma-related autoantibodies. Each autoantibody (and combinations of autoantibodies) has been associated with clinical subsets of scleroderma.

Reference: M. Y. Choi and M. J. Fritzler. Progress in understanding the diagnostic and pathogenic role of autoantibodies associated with systemic sclerosis. Curr.Opin.Rheumatol. 28:589-594, 2016.

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