Anti-SMN / GEMIN1 / RuvBL1/B2

IgG, LDT

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ANTIGENS / BIOMARKERS

Anti-SMN/Gemin 1 (IgG)

SKU / TEST CODE

SMN

PROCEDURE / TECHNIQUE

Addressable LASER Bead Immunoassay (ALBIA)

REFERENCE RANGE

Qualitative Analysis: Neg /Positive

SENSITIVITY / SPECIFICITY

TBD

CLINICAL ASSOCIATIONS

Mitogen’s Anti-SMN 45 assay is an autoimmune diagnostic test that detects autoantibodies to a protein named “Survival of Motor Neuron” (SMN 45). Antibodies to SMN and related components called ‘gemins’ have been reported in patients with a SLE/autoimmune myositis overlap syndrome and in necrotizing myositis. SMN (Survival of motor neuron 1 or component of gems 1 or GEMIN1) is a protein found in the cytoplasm and in the nuclear gems. SMN is involved in in transcriptional regulation, telomerase regeneration and cellular trafficking.

References:
A. Amlani, G. S. Hazlewood, L. Hamilton, M. Satoh, and M. J. Fritzler. Autoantibodies to the survival of motor neuron complex in a patient with necrotizing autoimmune myopathy. Rheumatology (Oxford). 57:199-200, 2018.
A. Amlani, et al. Rheumatology (Oxford). 57:199-200, 2018.