Diagnostic Tests

CLINICAL ASSOCIATIONS

Alongside the detection of autoantibodies against PLA2R (phospholipase A2 receptor), MitogenDx offers serological detection of autoantibodies against THSD7A (thrombospondin type-1 domain-containing protein 7A). This autoimmune diagnostic test contributes significantly to the diagnosis of primary membranous nephropathy (pMN), also known as primary membranous glomerulonephritis (pMGN). THSD7A plays a role in actin cytoskeleton rearrangement, promotes endothelial cell migration, angiogenesis, and cell differentiation.

Reference: C. Meyer-Schwesinger, G. Lambeau, and R. A. Stahl. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N.Engl.J.Med. 372:1074-1075, 2015.