Diagnostic Tests

Cytoplasmic Dot Test Panel

ANTIGENS / BIOMARKERS

Anti-GW182, GE-1, Ago2, EEA1

TURNAROUND-TIME (TAT)

5 Days

SKU / TEST CODE

CytoDots

PROCEDURE / TECHNIQUE

Addressable LASER Bead Immunoassay (ALBIA)

REFERENCE RANGE

Qualitative (Negative / Positive)

SENSITIVITY / SPECIFICITY

TBD

CLINICAL ASSOCIATIONS

Mitogen’s Cytoplasmic Dot Profile is an exclusive autoimmune diagnostic test that is used to confirm antibodies to targets represented by the HEp-2 IFA pattern reported as cytoplasmic discrete dots (AC-18). This panel detects autoantibodies against the antigen proteins that make up GW bodies (miRNA processing bodies) and early endosomes (EEA-1). Patients (>70%) with antibodies to GWB and EEA1 have a variety of autoimmune conditions that include idiopathic ataxia, primary biliary cholangitis and Sjögren syndrome.

Refer to: LM Stinton, et al. Clin.Immunol. 110:30-44, 2004; R. Bhanji, et al. Clin Immunol 123:247-256, 2007.

Other Tests To Consider