Cytoplasmic Dot Panel
LDT
ANTIGENS / BIOMARKERS
Anti-GW182, GE-1, Ago2, Early Endosome Antigen 1 (EEA-1)
TURNAROUND-TIME (TAT)
5-7 Days
SKU / TEST CODE
CYTOPD
PROCEDURE / TECHNIQUE
Addressable LASER Bead Immunoassay (ALBIA)
REFERENCE RANGE
Qualitative (Negative / Positive)
SENSITIVITY / SPECIFICITY
TBD
CLINICAL ASSOCIATIONS
Mitogen’s Cytoplasmic Dot Profile is an exclusive autoimmune diagnostic test that is used to confirm antibodies to targets represented by the HEp-2 IFA pattern reported as cytoplasmic discrete dots (AC-18). This panel detects autoantibodies against the antigen proteins that make up GW bodies (miRNA processing bodies) and early endosomes (EEA-1). Patients (>70%) with antibodies to GWB and EEA1 have a variety of autoimmune conditions that include idiopathic ataxia, primary biliary cholangitis and Sjögren syndrome.
Refer to: LM Stinton, et al. Clin.Immunol. 110:30-44, 2004; R. Bhanji, et al. Clin Immunol 123:247-256, 2007.
RELEVANT DISEASES
- Arthritis (Juvenile arthritis / Juvenile idiopathic arthritis)
- Ataxia/ idiopathic ataxia
- Autoimmune liver diseases
- Juvenile dermatomyositis (JDM)
- Lupus, Systemic lupus erythematous (SLE)
- Primary biliary cholangitis
- Primary biliary cholangitis
- Scleroderma / systemic sclerosis
- Sjögren’s syndrome
- Systemic lupus erythematous (SLE)
PRICES
Health Providers & Labs |
Please inquire for pricing |
Direct to Customer / Patient |
Currently not available |
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