Nucleolar Autoantibody Panel

ANA + Scleroderma Antigens

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ANTIGENS / BIOMARKERS

ANA + Anti-CENP A, CENP B, Topo-I/Scl-70, RP11, RP155, Anti fibrillarin/U3RNP, Th/To/hPOP1, Ku, PDGFR, Ro52/TRIM21, PM/Scl-75, PM/Scl-100, NOR90/Hubf

SKU / TEST CODE

NUC

PROCEDURE / TECHNIQUE

Immunofluorescence Assay (IFA), Line Immunoassay (LIA)

REFERENCE RANGE

Qualitative (SI :Signal Intensity) • Negative <10 SI • Weak Positive 11-29 SI • Medium Positive 30-89 SI • High positive >90 SI

SENSITIVITY / SPECIFICITY

TBD

CLINICAL ASSOCIATIONS

Mitogen’s Nucleolar Autoantibody Profile is an autoimmune diagnostic test that identifies anti-nucleolar antibodies that are often a challenge to detect and identify by HEp-2 IFA (AC-1, 8, 9, 10). Historically, anti-nucleolar antibodies were primarily associated with scleroderma. However, they are seen in a wide variety of other conditions.