What is the difference between the anti-cellular antibody test and the anti-nuclear antibody test?

Both tests use basically the same technology and assay – an indirect immunofluoresence assay (IFA) on HEp-2 cell substrates. The main difference is that many labs that perform the anti-nuclear antibody (ANA) test only report antibodies that react with the cell nucleus, while ignoring a wide spectrum of clinically-relevant autoantibodies that react with the cytoplasm and mitotic or cell cycle targets. Hence, the term ANA is restrictive, and the term anti-cell/cellular antibodies is more comprehensive and complete.