Anti-Myelin Associated Glycoproteins (MAG)
Line Immunoassay (LIA)
Qualitative Analysis: Negative / Positive
Mitogen’s assay for anti‐myelin associated glycoproteins (MAG) is an autoimmune diagnostic test that detects autoantibodies to MAG. Myelin-associated glycoprotein (MAG or Siglec-4) is a type 1 transmembrane glycoprotein localized in periaxonal Schwann cell and oligodendrocyte membranes. MAG is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor. In addition to being a ligand, MAG plays a role in glial-axonal interactions and is believed to be involved in myelination during nerve regeneration and is vital for the long-term survival of the myelinated axons following myelinogenesis. In the CNS MAG is one of the main myelin-associated inhibitors of axonal regeneration after injury.
MAG autoantibodies are typically associated with autoimmune peripheral neuropathies which can involve axonal degeneration / demyelination and can be acute or chronic, . The result from this autoimmune diagnostic test should be used as an aid to diagnosis since a positive result can be seen in other autoimmune disease and/or certain infectious disease.
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McKerracher L, et al. (October 1994). “Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth”. Neuron. 13 (4): 805–11. doi:10.1016/0896-6273(94)90247-x. PMID 7524558.
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