DISEASES
description
Necrotizing myositis (NM) is a subset of autoimmune myositis (AIM), and is distinguished by severe necrosis of skeletal muscle without overt evidence of severe inflammation. NM has been associated with statin (blood cholesterol lowering drugs) but is also seen in patients who are not on those drugs. Antibody markers called anti anti-3- hydroxy-3-methylglutaryl-CoA reductase (HMGCR), anti-signal recognition partner (SRP), and anti-SRP are markers of NM. There are case reports of anti-SMN and anti-nuclear envelope antibodies associated with NM.
Symptoms
- Weakness in the muscles closest to the center of the body, such as the forearms, thighs, hips, shoulders, neck, and back
- Difficulty climbing stairs and standing up from a chair
- Difficulty lifting arms over the head
- Falling and difficulty getting up from a fall
- A general feeling of tiredness